Neil LaBute, the innovative director of In the Company of Men and Your Friends and Neighbors, chose this script by John C. Richards and James Flamberg as the first one not written by himself for his third film. It was winner of the Best Screenplay Award at the 2000 Cannes Film Festival. In a brief and whimsical introduction, LaBute calls Nurse Betty a drama about "the way reality and fantasy can so easily bend our will." He also thinks it explores the way in which some people have to go a little crazy to find themselves.

In a foreword, the screenplay writers discuss their views on the film. This tie-in book also contains the film's full credits and 20 stills. Fans of Nurse Betty will savor the opportunity to join the waitress from Kansas City on her pilgrimage to Los Angeles to find love. I enjoyed revisiting the linchpin scene between Betty and Ellen, a bartender who tells her about the best thing she ever did — taking a trip to Rome on her own. Equally fascinating is following Charlie's fantasy trips as he tries to imagine the kind of person Betty really is. There are many routes individuals can take to personal transformation. Nurse Betty explores a unique and engaging one.