Blake Allen (Robert Downey, Jr.) is a New York City actor who lives in a fancy Soho loft. When he arrives home after a two-week trip to Los Angeles, two women are waiting for him. Lou (Natasha Gregson Wagner) is perky and streetwise; Carla (Heather Graham), a designer, comes across as more sophisticated and self-confident. They've just discovered that Blake has been dating both of them for the past ten months, professing undiluted loyalty and love to each. Feeling angry, betrayed, and curious, they want to know why. Blake, who is a compulsive liar and a sex addict, slips and slides around their attempts to understand. And, of course, he's unwilling to repent.

Two Girls and a Guy is written and directed by James Toback. The theme song, which gets several playings, is appropriately "You Don't Know Me." Downey gives a tour de force performance as the chameleon whose only true love is his ailing mother. Lou's and Carla's responses to Blake's feigned suicide, sexual prowess, and Shakespearean antics are surprising. The film provides a zany and somewhat twisted look at three New York singletons and their quest for love.