In Fools Rush In, Alex Whitman (Matthew Perry) meets Isabel Fuentes (Salma Hayek) who tells him that destiny has brought them together. Alex, a pragmatic New Yorker who only believes in the fast track he's taking at a firm that builds nightclubs, is from a wealthy and alienated family that has no intimacy. She's a Catholic from a large Mexican family whose members meet once a week to be with each other.

After one evening with Alex, Isabel shows up three months later to announced she's pregnant and wants to keep the baby. He impulsively marries her in a Vegas wedding parlor. Living together, they begin to realize how far apart they are in their upbringing and values. Isabel believes that God has a master plan for each person and the trick in life is to read the signs. He doesn't agree with any of that until a clergyman in New York says to him, "You look lost. There are signs everywhere to help you find your way." And sure enough, the way leads away from rationality and into the mystery of the heart.

This comedy directed by Andy Tennant celebrates the truth Sufi poet Rumi understood long ago: "Lovers don't finally meet somewhere. They're in each other all along."